An improved method for acquiring cerebrovascular reactivity maps
Article first published online: 8 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 65, Issue 5, pages 1278–1286, May 2011
How to Cite
Blockley, N. P., Driver, I. D., Francis, S. T., Fisher, J. A. and Gowland, P. A. (2011), An improved method for acquiring cerebrovascular reactivity maps. Magn Reson Med, 65: 1278–1286. doi: 10.1002/mrm.22719
- Issue published online: 15 APR 2011
- Article first published online: 8 DEC 2010
- Manuscript Accepted: 17 OCT 2010
- Manuscript Revised: 5 OCT 2010
- Manuscript Received: 2 AUG 2010
- UK Medical Research Council and Engineering and Physical Sciences Research Council
- Cerebrovascular Reactivity, Magnetic Resonance Imaging, Hypercapnic Challenge, BOLD
This study aims to improve the method used to produce cerebrovascular reactivity (CVR) maps by MRI. Previous methods have used a standard boxcar presentation of carbon dioxide (CO2). Here this is replaced with a sinusoidally modulated CO2 stimulus. This allowed the use of Fourier analysis techniques to measure both the amplitude and phase delay of the BOLD CVR response, and hence characterize the arrival sequence of blood to different regions of the brain. This characterization revealed statistically significant relative delays between regions of the brain (ANOVA < 0.0001). In addition, post hoc comparison showed that the frontal (P < 0.001) and parietal (P = 0.004) lobes reacted earlier than the occipital lobe. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc.