Validity of perfusion parameters obtained using the modified Tofts model: A simulation study
Article first published online: 16 DEC 2010
Copyright © 2010 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 65, Issue 5, pages 1491–1497, May 2011
How to Cite
Luypaert, R., Sourbron, S. and de Mey, J. (2011), Validity of perfusion parameters obtained using the modified Tofts model: A simulation study. Magn Reson Med, 65: 1491–1497. doi: 10.1002/mrm.22728
- Issue published online: 15 APR 2011
- Article first published online: 16 DEC 2010
- Manuscript Accepted: 25 OCT 2010
- Manuscript Revised: 28 SEP 2010
- Manuscript Received: 2 JUL 2010
- Tofts model;
The two-compartment Tofts model (2CTM) has had widespread use in research and clinical practice. It assumes there is no broadening associated with the bolus transit through the capillary bed of the tissue under study. This assumption is often violated, with consequences that are hard to predict intuitively. The two-compartment exchange model is a generalization of 2CTM obtained by dropping the zero-broadening hypothesis, making it suitable for estimating the impact of violating this assumption. Using data simulated on the basis of the two-compartment exchange model, the correspondence between the hemodynamic parameters serving as input for the two-compartment exchange model and the parameters resulting from fitting the data with the 2CTM was investigated. The influence of tissue type and experimental setup was studied. Generally, a large tissue and setup dependent bias of the 2CTM fitting results with respect to the two-compartment exchange model input was observed. Extreme caution is needed when interpreting 2CTM data. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc.