Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T
Article first published online: 10 MAR 2011
Copyright © 2011 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 65, Issue 5, pages 1239–1246, May 2011
How to Cite
MacMillan, E. L., Chong, D. G. Q., Dreher, W., Henning, A., Boesch, C. and Kreis, R. (2011), Magnetization exchange with water and T1 relaxation of the downfield resonances in human brain spectra at 3.0 T. Magn Reson Med, 65: 1239–1246. doi: 10.1002/mrm.22813
- Issue published online: 15 APR 2011
- Article first published online: 10 MAR 2011
- Manuscript Accepted: 14 DEC 2010
- Manuscript Revised: 30 NOV 2010
- Manuscript Received: 19 SEP 2010
- proton MR spectroscopy;
- exchangeable protons;
The use of water suppression for in vivo proton MR spectroscopy diminishes the signal intensities from resonances that undergo magnetization exchange with water, particularly those downfield of water. To investigate these exchangeable resonances, an inversion transfer experiment was performed using the metabolite cycling technique for non-water-suppressed MR spectroscopy from a large brain voxel in 11 healthy volunteers at 3.0 T. The exchange rates of the most prominent peaks downfield of water were found to range from 0.5 to 8.9 s−1, while the T1 relaxation times in absence of exchange were found to range from 175 to 525 ms. These findings may help toward the assignments of the downfield resonances and a better understanding of the sources of contrast in chemical exchange saturation transfer imaging. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.