Accelerated T2 mapping for characterization of prostate cancer
Article first published online: 10 MAR 2011
Copyright © 2011 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 65, Issue 5, pages 1400–1406, May 2011
How to Cite
Liu, W., Turkbey, B., Sénégas, J., Remmele, S., Xu, S., Kruecker, J., Bernardo, M., Wood, B. J., Pinto, P. A. and Choyke, P. L. (2011), Accelerated T2 mapping for characterization of prostate cancer. Magn Reson Med, 65: 1400–1406. doi: 10.1002/mrm.22874
- Issue published online: 15 APR 2011
- Article first published online: 10 MAR 2011
- Manuscript Accepted: 20 JAN 2011
- Manuscript Revised: 15 JAN 2011
- Manuscript Received: 18 OCT 2010
- prostate cancer;
- k-space undersampling;
- T2 mapping
Prostate T2 mapping was performed in 34 consecutive patients using an accelerated multiecho spin-echo sequence with 4-fold k-space undersampling leading to a net acceleration factor of 3.3 on a 3T scanner. The mean T2 values from the accelerated and conventional, unaccelerated sequences demonstrated a very high correlation (r = 0.99). Different prostate segments demonstrated similarly good interscan reproducibility (p = not significant) with slightly larger difference at base: 2.0% ± 1.6% for left base and 2.1% ± 1.1% for right base. In patients with subsequent targeted biopsy, T2 values of histologically proven malignant tumor areas were significantly lower than the suspicious looking but nonmalignant lesions (p < 0.05) and normal areas (p < 0.001): 100 ± 10 ms for malignant tumors, 114 ± 23 ms for suspicious lesions and 149 ± 32 ms for normal tissues. The proposed method can provide an effective approach for accelerated T2 quantification for prostate patients. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc.