• 1
    Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, Karim R, Lin R, Samarasinghe D, Liddle C, Weltman M, George J. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373379.
  • 2
    Harrison SA, Neuschwander-Tetri BA. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Clin Liver Dis 2004; 8: 861879, ix.
  • 3
    Papandreou D, Rousso I, Mavromichalis I. Update on non-alcoholic fatty liver disease in children. Clin Nutr 2007; 26: 409415.
  • 4
    Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I, Kusano Y. Prevalence of fatty liver in Japanese children and relationship to obesity. an epidemiological ultrasonographic survey. Dig Dis Sci 1995; 40: 20022009.
  • 5
    Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006; 118: 13881393.
  • 6
    Angulo P, Lindor KD. Non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2002; 17 ( Suppl): S186S190.
  • 7
    Rydell J, Knutsson H, Pettersson J, Johansson A, Farneback G, Dahlqvist O, Lundberg P, Nystrom F, Borga M. Phase sensitive reconstruction for water/fat separation in MR imaging using inverse gradient. Med Image Comput Comput Assist Interv 2007; 10 ( Pt 1): 210218.
  • 8
    Cowin GJ, Jonsson JR, Bauer JD, Ash S, Ali A, Osland EJ, Purdie DM, Clouston AD, Powell EE, Galloway GJ. Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. J Magn Reson Imaging 2008; 28: 937945.
  • 9
    Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin CB. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging 2008; 26: 347359.
  • 10
    Hines CD, Yu H, Shimakawa A, McKenzie CA, Brittain JH, Reeder SB. T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom. J Magn Reson Imaging 2009; 30: 12151222.
  • 11
    Guiu B, Petit JM, Loffroy R, Ben Salem D, Aho S, Masson D, Hillon P, Krause D, Cercueil JP. Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy. Radiology 2009; 250: 95102.
  • 12
    Yokoo T, Bydder M, Hamilton G, Middleton MS, Gamst AC, Wolfson T, Hassanein T, Patton HM, Lavine JE, Schwimmer JB, Sirlin CB. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology 2009; 251: 6776.
  • 13
    Hu HH, Kim HW, Nayak KS, Goran MI. Comparison of fat–water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 2010; 18: 841847.
  • 14
    Hines CD, Yu H, Shimakawa A, McKenzie CA, Warner TF, Brittain JH, Reeder SB. Quantification of hepatic steatosis with 3-T MR imaging: validation in ob/ob mice. Radiology 2010; 254: 119128.
  • 15
    Reeder SB, Pineda AR, Wen Z, Shimakawa A, Yu H, Brittain JH, Gold GE, Beaulieu CH, Pelc NJ. Iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): application with fast spin-echo imaging. Magn Reson Med 2005; 54: 636644.
  • 16
    Hernando D, Haldar JP, Sutton BP, Ma J, Kellman P, Liang ZP. Joint estimation of water/fat images and field inhomogeneity map. Magn Reson Med 2008; 59: 571580.
  • 17
    Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB. Multiecho water–fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008; 60: 11221134.
  • 18
    Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007; 58: 354364.
  • 19
    Yu H, Shimakawa A, Reeder S, McKenzie C, Brittain J. Magnitude fitting following phase sensitive water–fat separation to remove effects of phase errors. In: Proceedings of the 17th Scientific Meeting of ISMRM, Honolulu, HI, 2009. p. 461.
  • 20
    Yu H, McKenzie CA, Shimakawa A, Vu AT, Brau AC, Beatty PJ, Pineda AR, Brittain JH, Reeder SB. Multiecho reconstruction for simultaneous water–fat decomposition and T2* estimation. J Magn Reson Imaging 2007; 26: 11531161.
  • 21
    Chebrolu VV, Hines CD, Yu H, Pineda AR, Shimakawa A, McKenzie CA, Samsonov A, Brittain JH, Reeder SB. Independent estimation of T*2 for water and fat for improved accuracy of fat quantification. Magn Reson Med 2010; 63: 849857.
  • 22
    O'Regan DP, Callaghan MF, Wylezinska-Arridge M, Fitzpatrick J, Naoumova RP, Hajnal JV, Schmitz SA. Liver fat content and T2*: simultaneous measurement by using breath-hold multiecho MR imaging at 3.0 T—feasibility. Radiology 2008; 247: 550557.
  • 23
    Szczepaniak LS, Nurenberg P, Leonard D, Browning JD, Reingold JS, Grundy S, Hobbs HH, Dobbins RL. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005; 288: E462E468.
  • 24
    Pineda AR, Reeder SB, Wen Z, Pelc NJ. Cramer-Rao bounds for three-point decomposition of water and fat. Magn Reson Med 2005; 54: 625635.
  • 25
    Hernando D, Liang Z-P, Kellman P. Comparison of magnitude and complex data fitting for quantitative water/fat imaging. In Proceedings 18th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, 2010. p. 5098.
  • 26
    Hernando D, Liang Z-P, Kellman P. Modeling of T2* decay in water/fat imaging: comparison of one-decay and two-decay models. In Proceedings 18th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, 2010. p. 5095.
  • 27
    Hernando D, Liang ZP, Kellman P. Chemical shift–based water/fat separation: a comparison of signal models. Magn Reson Med 2010; 64: 811822.
  • 28
    Eldar YC. Minimum variance in biased estimation: bounds and asymptotically optimal estimators. IEEE Trans Signal Processing 2004; 52: 19151930.
  • 29
    Hussain HK, Chenevert TL, Londy FJ, Gulani V, Swanson SD, McKenna BJ, Appelman HD, Adusumilli S, Greenson JK, Conjeevaram HS. Hepatic fat fraction: MR imaging for quantitative measurement and display—early experience. Radiology 2005; 237: 10481055.
  • 30
    Reeder S, Hines C, Yu H, McKenzie C, Brittain J. On The definition of fat-fraction for in vivo fat quantification with magnetic resonance imaging. In Proceedings of the 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawaii, April 2009. p. 211.
  • 31
    Hamilton G, Yokoo T, Bydder M, Cruite I, Schroeder ME, Sirlin CB, Middleton MS. In vivo characterization of the liver fat (1)H MR spectrum. NMR Biomed 2010 [Epub ahead of print].
  • 32
    de Graaf R, Rothman D. In vivo detection and quantification of scalar coupled (1)H NMR resonances. Concepts Magn Reson 2001; 13: 3276.
  • 33
    Hamilton G, Middleton MS, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin CB. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging 2009; 30: 145152.
  • 34
    Meisamy S, Hines CD, Hamilton G, Sirlin CB, McKenzie CA, Yu H, Brittain JH, Reeder SB. Quantification of hepatic steatosis with T1-independent, T2*-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology 2011; 258: 767775.
  • 35
    McVeigh ER, Henkelman RM, Bronskill MJ. Noise and filtration in magnetic resonance imaging. Med Phys 1985; 12: 586591.
  • 36
    Mood, AM, Graybill FA, Boes, DC. Introduction to the theory of statistics. NY: McGraw-Hill; 1974.
  • 37
    Glover GH. Multipoint Dixon technique for water and fat proton and susceptibility imaging. J Magn Reson Imaging 1991; 1: 521530.
  • 38
    Schwenzer NF, Machann J, Haap MM, Martirosian P, Schraml C, Liebig G, Stefan N, Haring HU, Claussen CD, Fritsche A, Schick F. T2* relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-nine subjects-correlation with age, gender, and serum ferritin. Invest Radiol 2008; 43: 854860.
  • 39
    Brau AC, Beatty PJ, Skare S, Bammer R. Comparison of reconstruction accuracy and efficiency among autocalibrating data-driven parallel imaging methods. Magn Reson Med 2008; 59: 382395.
  • 40
    Yu H, Reeder SB, Shimakawa A, Brittain JH, Pelc NJ. Field map estimation with a region growing scheme for iterative 3-point water-fat decomposition. Magn Reson Med 2005; 54: 10321039.
  • 41
    Chebrolu VV, Yu H, Pineda AR, McKenzie CA, Brittain JH, Reeder SB. Noise analysis for 3-point chemical shift-based water-fat separation with spectral modeling of fat. J Magn Reson Imaging 2010; 32: 493500.
  • 42
    Van Trees HL. Detection, estimation, and modulation theory. New York: Wiley; 1968.