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Localized in vivo hyperpolarization transfer sequences

Authors

  • Mor Mishkovsky,

    Corresponding author
    1. Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    2. Department of Radiology, University of Lausanne, Lausanne, Switzerland
    • Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), EPFL-SB-IPMC-LIFMET, Station 6, CH-1015 Lausanne (VD), Switzerland
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  • Tian Cheng,

    1. Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
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  • Arnaud Comment,

    1. Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    2. Institute of Condensed Matter Physics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
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  • Rolf Gruetter

    1. Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
    2. Department of Radiology, University of Lausanne, Lausanne, Switzerland
    3. Department of Radiology, Geneva University Hospital and Faculty of Medicine, University of Geneva, Geneva 4, Switzerland
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Abstract

In vivo localized and fully adiabatic homonuclear and heteronuclear polarization transfer experiments were designed and performed in the rat brain at 9.4 T after infusion of hyperpolarized sodium [1,2-13C2] and sodium [1-13C] acetate. The method presented herein leads to highly enhanced in vivo detection of short-T1 13C as well as attached protons. This indirect detection scheme allows for probing additional molecular sites in hyperpolarized substrates and their metabolites and can thus lead to improved spectral resolution such as in the case of 13C-acetate metabolism. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

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