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Effect of protocol parameters on contrast agent washout curve separability in breast dynamic contrast enhanced MRI: A simulation study†
Article first published online: 5 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 68, Issue 2, pages 516–522, August 2012
How to Cite
Freed, M. (2012), Effect of protocol parameters on contrast agent washout curve separability in breast dynamic contrast enhanced MRI: A simulation study. Magn Reson Med, 68: 516–522. doi: 10.1002/mrm.23234
- Issue published online: 12 JUL 2012
- Article first published online: 5 DEC 2011
- Manuscript Accepted: 6 SEP 2011
- Manuscript Revised: 9 AUG 2011
- Manuscript Received: 25 APR 2011
- FDA's Office of Womens Health and an appointment to the Research Participation Program at the Center for Devices and Radiological Health administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the U.S. Food and Drug Administration
- breast DCE-MRI;
Variability in diagnostic performance of breast dynamic contrast-enhanced MRI has highlighted the need for improved standardization. While guidance exists on some aspects of the technique, currently, there is no standardized method for selecting repetition time and flip angle, which are important determinants of image contrast. This study develops a theoretical framework for quantitative optimization of temporal aspects of dynamic contrast-enhanced MRI based on area under the receiver operating curve. Optimizations in simulation demonstrate the potential for increases in area under the receiver operating characteristic curve by up to 0.20 and specificity at a sensitivity of 90% by up to 19%, depending on the protocol. These results suggest that careful selection of repetition time and flip angle can improve diagnostic performance and identify these quantities as potentially important parameters for future standardization. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.