A simple isotropic phantom for diffusional kurtosis imaging
Version of Record online: 8 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 68, Issue 2, pages 537–542, August 2012
How to Cite
Fieremans, E., Pires, A. and Jensen, J. H. (2012), A simple isotropic phantom for diffusional kurtosis imaging. Magn Reson Med, 68: 537–542. doi: 10.1002/mrm.23263
- Issue online: 12 JUL 2012
- Version of Record online: 8 DEC 2011
- Manuscript Accepted: 30 SEP 2011
- Manuscript Revised: 8 SEP 2011
- Manuscript Received: 14 JUL 2011
Dairy cream is shown to be a simple, inexpensive, isotropic phantom useful for testing diffusional kurtosis imaging data acquisition and postprocessing. The MR-visible protons of cream exhibit slow and fast diffusion components, attributed to the fat and water protons, respectively, which give rise to a diffusion coefficient of 1.1 μm2/ms and a diffusional kurtosis of 1.2. These parameter values are similar to those observed in vivo for human brain. Heating the cream is found to increase the T2-relaxation time of the fat protons, which facilitates the evaluation of typical diffusional kurtosis imaging protocols used in clinical settings. The diffusion coefficient and diffusional kurtosis can both be measured directly and predicted based on the corresponding diffusion parameters of the individual water and fat components, which are independently measurable due to chemical shift misregistration, thus providing an important consistency check. This phantom is proposed as a convenient calibration standard for multicenter diffusional kurtosis imaging studies. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.