Get access

Diffusion-prepared fast imaging with steady-state free precession (DP-FISP): A rapid diffusion MRI technique at 7 T

Authors

  • Lan Lu,

    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Bernadette Erokwu,

    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Gregory Lee,

    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Vikas Gulani,

    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Mark A. Griswold,

    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Katherine M. Dell,

    1. CWRU Center for the Study of Kidney Disease and Biology, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Search for more papers by this author
  • Chris A. Flask

    Corresponding author
    1. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    • Ph.D., Assistant Professor of Radiology and Biomedical Engineering, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Bolwell Building, Room B115, Cleveland, OH 44106
    Search for more papers by this author

Abstract

Diffusion MRI is a useful imaging technique with many clinical applications. Many diffusion MRI studies have utilized echo-planar imaging (EPI) acquisition techniques. In this study, we have developed a rapid diffusion-prepared fast imaging with steady-state free precession MRI acquisition for a preclinical 7T scanner providing diffusion-weighted images in less than 500 ms and diffusion tensor imaging assessments in ∼1 min with minimal image artifacts in comparison with EPI. Phantom apparent diffusion coefficient (ADC) and fractional anisotropy (FA) assessments obtained from the diffusion-prepared fast imaging with steady-state free precession (DP-FISP) acquisition resulted in good agreement with EPI and spin echo diffusion methods. The mean apparent diffusion coefficient was 2.0 × 10−3 mm2/s, 1.90 × 10−3 mm2/s, and 1.97 × 10−3 mm2/s for DP-FISP, diffusion-weighted spin echo, and diffusion-weighted EPI, respectively. The mean fractional anisotropy was 0.073, 0.072, and 0.070 for diffusion-prepared fast imaging with steady-state free precession, diffusion-weighted spin echo, and diffusion-weighted EPI, respectively. Initial in vivo studies show reasonable ADC values in a normal mouse brain and polycystic rat kidneys. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary