Resolution enhanced T1-insensitive steady-state imaging

Authors

  • Jamal J. Derakhshan,

    1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Radiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, USA
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  • Sherif G. Nour,

    1. Department of Radiology, Emory University, Atlanta, Georgia, USA (current)
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  • Jeffrey L. Sunshine,

    1. Department of Radiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, USA
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  • Mark A. Griswold,

    1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Radiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, USA
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  • Jeffrey L. Duerk

    Corresponding author
    1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    2. Department of Radiology, Case Western Reserve University/University Hospitals of Cleveland, Cleveland, Ohio, USA
    • Department of Radiology-MRI, University Hospitals-Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106
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Abstract

Resolution enhanced T1-insensitive steady-state imaging (RE-TOSSI) is a new MRI pulse sequence for the generation of rapid T2 contrast with high spatial resolution. TOSSI provides T2 contrast by using nonequally spaced inversion pulses throughout a balanced steady-state free precession (SSFP) acquisition. In RE-TOSSI, these energy and time intensive adiabatic inversion pulses and associated magnetization preparation are removed from TOSSI after acquisition of the data around the center of k-space. Magnetization evolution simulations demonstrate T2 contrast in TOSSI as well as reduction in the widening of the point spread function width (by up to a factor of 4) to a near ideal case for RE-TOSSI. Phantom experimentation is used to characterize and compare the contrast and spatial resolution properties of TOSSI, RE-TOSSI, balanced SSFP, Half-Fourier Acquisition Single-Shot Turbo Spin Echo (HASTE), and turbo spin echo and to optimize the fraction of k-space acquired using TOSSI. Comparison images in the abdomen and brain demonstrate similar contrast and improved spatial resolution in RE-TOSSI compared with TOSSI; comparison balanced SSFP, HASTE, and turbo spin echo images are provided. RE-TOSSI is capable of providing high spatial resolution T2-weighted images in 1 s or less per image. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.

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