Keyhole chemical exchange saturation transfer
Article first published online: 13 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 68, Issue 4, pages 1228–1233, October 2012
How to Cite
Varma, G., Lenkinski, R. E. and Vinogradov, E. (2012), Keyhole chemical exchange saturation transfer. Magn Reson Med, 68: 1228–1233. doi: 10.1002/mrm.23310
- Issue published online: 24 SEP 2012
- Article first published online: 13 JAN 2012
- Manuscript Accepted: 6 NOV 2011
- Manuscript Revised: 11 OCT 2011
- Manuscript Received: 19 AUG 2011
- NIH. Grant Number: R21 EB009425
- generalized series
The keyhole technique, which involves the acquisition of dynamic data at low resolution in combination with a high-resolution reference, is developed for the purposes of chemical exchange saturation transfer (CEST) imaging, i.e., Keyhole CEST. Low-resolution data are acquired with saturation applied at different frequencies for Z-spectra, along with a high-resolution reference image taken without saturation. Three methods for high-resolution reconstruction of Keyhole CEST are evaluated using the values from quantitative high-resolution CEST maps. In addition, Keyhole CEST is applied for collection of data used for B0 correction. The keyhole approach is evaluated for CEST contrast generation using exchanging protons in hydroxyl groups. First, the techniques are evaluated in vitro using samples of dextrose and chondroitin sulfate. Next, the work is extended in vivo to explore its applicability for gagCEST. Comparable quantitative gagCEST values are found using Keyhole CEST, provided the structure or region of interest is not limited by the low-resolution dataset. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.