Dynamic hysteresis between gradient echo and spin echo attenuations in dynamic susceptibility contrast imaging
Article first published online: 18 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 69, Issue 4, pages 981–991, April 2013
How to Cite
Xu, C., Kiselev, V. G., Möller, H. E. and Fiebach, J. B. (2013), Dynamic hysteresis between gradient echo and spin echo attenuations in dynamic susceptibility contrast imaging. Magn Reson Med, 69: 981–991. doi: 10.1002/mrm.24326
- Issue published online: 20 MAR 2013
- Article first published online: 18 MAY 2012
- Manuscript Accepted: 13 APR 2012
- Manuscript Revised: 9 MAR 2012
- Manuscript Received: 20 DEC 2011
- dynamic susceptibility contrast;
- transverse relaxation rate constant;
Perfusion measurements using dynamic susceptibility contrast imaging provide additional information about the mean vessel size of microvasculature when supplemented with a dual gradient echo (GE) – spin echo (SE) contrast. Dynamic increase in the corresponding transverse relaxation rate constant changes, ΔR2GE and ΔR2SE, forms a loop on the (Δ, ΔR2GE) plane, rather than a reversible line. The shape of the loop and the direction of its passage differentiate between healthy brain and pathological tissue, such as tumour and ischemic tissue. By considering a tree model of microvasculature, the direction of the loop is found to be influenced mainly by the relative arterial and venous blood volume, as well as the tracer bolus dispersion. A parameter Λ is proposed to characterize the direction and shape of the loop, which might be considered as a novel imaging marker for describing the pathology of cerebrovascular network. Magn Reson Med 69:981–991, 2013. © 2012 Wiley Periodicals, Inc.