Volumetric measurement of perfusion and arterial transit delay using hadamard encoded continuous arterial spin labeling
Version of Record online: 22 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 69, Issue 4, pages 1014–1022, April 2013
How to Cite
Dai, W., Shankaranarayanan, A. and Alsop, D. C. (2013), Volumetric measurement of perfusion and arterial transit delay using hadamard encoded continuous arterial spin labeling. Magn Reson Med, 69: 1014–1022. doi: 10.1002/mrm.24335
- Issue online: 20 MAR 2013
- Version of Record online: 22 MAY 2012
- Manuscript Accepted: 24 APR 2012
- Manuscript Revised: 18 APR 2012
- Manuscript Received: 27 DEC 2011
- National Institutes of Health. Grant Number: CA115745, MH80729 and T32AG023480
Creating images of the transit delay from the labeling location to image tissue can aid the optimization and quantification of arterial spin labeling perfusion measurements and may provide diagnostic information independent of perfusion. Unfortunately, measuring transit delay requires acquiring a series of images with different labeling timing that adds to the time cost and increases the noise of the arterial spin labeling study. Here, we implement and evaluate a proposed Hadamard encoding of labeling that speeds the imaging and improves the signal-to-noise ratio efficiency. Volumetric images in human volunteers confirmed the theoretical advantages of Hadamard encoding over sequential acquisition of images with multiple labeling timing. Perfusion images calculated from Hadamard encoded acquisition had reduced signal-to-noise ratio relative to a dedicated perfusion acquisition with either assumed or separately measured transit delays, however. Magn Reson Med 69:1014–1022, 2013. © 2012 Wiley Periodicals, Inc.