Full Paper

EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate

  1. Shingo Matsumoto1,
  2. Keita Saito1,
  3. Hironobu Yasui1,2,
  4. H. Douglas Morris3,
  5. Jeeva P. Munasinghe3,
  6. Martin Lizak3,
  7. Hellmut Merkle3,
  8. Jan Henrik Ardenkjaer-Larsen4,5,
  9. Rajani Choudhuri1,
  10. Nallathamby Devasahayam1,
  11. Sankaran Subramanian1,
  12. Alan P. Koretsky3,
  13. James B. Mitchell1,
  14. Murali C. Krishna1,*

Article first published online: 12 JUN 2012

DOI: 10.1002/mrm.24355

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 69, Issue 5, pages 1443–1450, May 2013

Additional Information

How to Cite

Matsumoto, S., Saito, K., Yasui, H., Morris, H. D., Munasinghe, J. P., Lizak, M., Merkle, H., Ardenkjaer-Larsen, J. H., Choudhuri, R., Devasahayam, N., Subramanian, S., Koretsky, A. P., Mitchell, J. B. and Krishna, M. C. (2013), EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate. Magn Reson Med, 69: 1443–1450. doi: 10.1002/mrm.24355

Author Information

  1. 1

    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA

  2. 2

    Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

  3. 3

    Mouse Imaging Facility, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA

  4. 4

    GE Healthcare, Broendby, Denmark

  5. 5

    Technical University of Denmark, Lyngby, Denmark

*Ph.D., Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Building 10, Room B3B69, NIH, Bethesda, MD 20892-1002

Publication History

  1. Issue published online: 17 APR 2013
  2. Article first published online: 12 JUN 2012
  3. Manuscript Accepted: 8 MAY 2012
  4. Manuscript Revised: 7 MAY 2012
  5. Manuscript Received: 22 MAR 2012

Funded by

  • Intramural Research Program
  • Center for Cancer Research
  • National Cancer Institute
  • NIH
  • NCI
  • NINDS

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