4-T 7Li 3D MR spectroscopy imaging in the brains of bipolar disorder subjects
Article first published online: 12 JUN 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 68, Issue 2, pages 363–368, August 2012
How to Cite
Lee, J.-H., Adler, C., Norris, M., Chu, W.-J., Fugate, E. M., Strakowski, S. M. and Komoroski, R. A. (2012), 4-T 7Li 3D MR spectroscopy imaging in the brains of bipolar disorder subjects. Magn Reson Med, 68: 363–368. doi: 10.1002/mrm.24361
- Issue published online: 12 JUL 2012
- Article first published online: 12 JUN 2012
- Manuscript Accepted: 13 MAY 2012
- Manuscript Revised: 7 MAY 2012
- Manuscript Received: 15 NOV 2011
- University of Cincinnati Bipolar Disorder Imaging and Treatment Research Center through NIH. Grant Number: P50 MH077138
- bipolar disorder;
- Fourier transform
This work demonstrates the first whole brain “high spatial resolution” 7Li MR spectroscopy imaging in bipolar disorder subjects. The in vivo quantification is validated by a phantom containing 5 mM lithium salt using the identical radiofrequency sequence and imaging protocol. This study is the first demonstration of the 7Li distribution in the brain of bipolar disorder patients on lithium therapy using a 3D MR spectroscopy imaging approach. The results show that brain lithium level is strongly correlated with serum lithium concentration. The brain-to-serum lithium ratios for the average brain and the local maximum were 0.39 ± 0.08 (r = 0.93) and 0.92 ± 0.16 (r = 0.90), respectively. The lithium distribution is found to be nonuniform throughout the brain for all patients, which is somewhat unexpected and highly intriguing. This uneven distribution is more evident in subjects at a higher therapeutic serum lithium level. This finding may suggest that lithium targets specific brain tissues and/or certain enzymatic and macromolecular sites that are associated with therapeutic effect. Further investigations of bipolar disorder patients on lithium therapy using 3D 7Li MR spectroscopy imaging are warranted. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.