Longitudinal rotating frame relaxation time measurements in infarcted mouse myocardium in vivo

Authors

  • Haja-Sherief N. Musthafa,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Galina Dragneva,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Line Lottonen,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Mari Merentie,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Lyubomir Petrov,

    1. Ark Therapeutics Ltd., Kuopio, Finland
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  • Tommi Heikura,

    1. Ark Therapeutics Ltd., Kuopio, Finland
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  • Elias Ylä-Herttuala,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Seppo Ylä-Herttuala,

    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Olli Gröhn,

    1. Department of Neurobiology, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
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  • Timo Liimatainen

    Corresponding author
    1. Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
    • Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1, 70210 Kuopio, Finland
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Abstract

Longitudinal relaxation time in the rotating frame (T1ρ) was measured using continuous wave irradiation in normal and infarcted mouse myocardium in vivo. Significant increase in T1ρ was found after 7 days of infarction when compared with reference myocardium or in myocardium before infarction. Cine MRI and histology were performed to verify the severity of infarction. The time course of T1ρ in the infarct fits better with granulation and scar tissue formation than necrosis and edema. The results of the study show that T1ρ could potentially be a noninvasive quantitative marker for tissue remodeling after ischemic damage. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

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