Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA)

Authors

  • Daniel P. Fiege,

    1. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany
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  • Sandro Romanzetti,

    1. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany
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  • Christian C. Mirkes,

    1. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany
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  • Daniel Brenner,

    1. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany
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  • N. Jon Shah

    Corresponding author
    1. Institute of Neuroscience and Medicine-4, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, Germany
    2. Faculty of Medicine, Department of Neurology, RWTH Aachen University, JARA, Templergraben 55, Aachen, Germany
    • Institute of Neuroscience and Medicine-4, Medical Imaging Physics, Forschungszentrum, Jülich, Wilhelm-Johnen-Str., 52425 Jülich, Germany===

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Abstract

The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.

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