Mapping of oxygen by imaging lipids relaxation enhancement: A potential sensitive endogenous MRI contrast to map variations in tissue oxygenation

Authors

  • Bénédicte F. Jordan,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Julie Magat,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Florence Colliez,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Elif Ozel,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Anne-Catherine Fruytier,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Valérie Marchand,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Lionel Mignion,

    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Caroline Bouzin,

    1. Angiogenesis and Cancer Research Laboratory, Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium
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  • Patrice D. Cani,

    1. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Caroline Vandeputte,

    1. Biomedical MRI/Molecular Small Animal Imaging Center, Katholieke Universiteit Leuven, Leuven, Belgium
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  • Olivier Feron,

    1. Angiogenesis and Cancer Research Laboratory, Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium
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  • Nathalie Delzenne,

    1. Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
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  • Uwe Himmelreich,

    1. Biomedical MRI/Molecular Small Animal Imaging Center, Katholieke Universiteit Leuven, Leuven, Belgium
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  • Vincent Denolin,

    1. Philips Health Care, Benelux, Belgium
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  • Thierry Duprez,

    1. Radiology and Medical Imaging, St. Luc hospital, Institute of Neuroscience (IoNS), Université Catholique de Louvain, Brussels, Belgium
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  • Bernard Gallez

    Corresponding author
    1. Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
    • Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Av. Mounier, 73.08, B-1200 Brussels, Belgium. E-mail: bernard.gallez@uclouvain.be

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  • Disclosure: B.F.J., J.M., and B.G. declare a possible competing financial interest: they filed Patent applications 11163573.6-1265 and PCT/EP2012/057237.

Abstract

Purpose

Because of its paramagnetic properties, oxygen may act as an endogenous magnetic resonance imaging contrast agent by changing proton relaxation rates. Changes in tissue oxygen concentrations have been shown to produce changes in relaxation rate R1 of water. The aim of the study was to improve the sensitivity of oxygen enhanced R1 imaging by exploiting the higher solubility of oxygen in lipids (as compared with water) to sensitively monitor changes in tissue oxygen levels by selectively measuring the R1 of lipids.

Methods

The method, with the acronym “MOBILE” (mapping of oxygen by imaging lipids relaxation enhancement), was applied in different mouse models of hypoxic processes on a 11.7 T magnetic resonance imaging system. MOBILE was compared with R*2, R1 of water, and with pO2 measurements (using electron paramagnetic resonance oximetry). MOBILE was also applied in the brain of healthy human volunteers exposed to an oxygen breathing challenge on a 3 T magnetic resonance imaging system.

Results

MOBILE was shown to be able to monitor changes in oxygenation in tumor, peripheral, liver, and brain tissues. The clinical translation was demonstrated in human volunteers.

Conclusion

MOBILE arises as a promising noninvasive and sensitive tool for diagnosis and therapeutic guidance in disorders involving hypoxia. Magn Reson Med 70:732–744, 2013. © 2012 Wiley Periodicals, Inc.

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