Disclosure: B.F.J., J.M., and B.G. declare a possible competing financial interest: they filed Patent applications 11163573.6-1265 and PCT/EP2012/057237.
Mapping of oxygen by imaging lipids relaxation enhancement: A potential sensitive endogenous MRI contrast to map variations in tissue oxygenation†
Article first published online: 28 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 3, pages 732–744, September 2013
How to Cite
Jordan, B. F., Magat, J., Colliez, F., Ozel, E., Fruytier, A.-C., Marchand, V., Mignion, L., Bouzin, C., Cani, P. D., Vandeputte, C., Feron, O., Delzenne, N., Himmelreich, U., Denolin, V., Duprez, T. and Gallez, B. (2013), Mapping of oxygen by imaging lipids relaxation enhancement: A potential sensitive endogenous MRI contrast to map variations in tissue oxygenation. Magn Reson Med, 70: 732–744. doi: 10.1002/mrm.24511
- Issue published online: 27 AUG 2013
- Article first published online: 28 SEP 2012
- Manuscript Accepted: 31 AUG 2012
- Manuscript Revised: 30 AUG 2012
- Manuscript Received: 23 MAY 2012
- Actions de Recherches Concertées-Communauté Française de Belgique. Grant Number: ARC 09/14-020
- Pôle d'Attraction Interuniversitaire. Grant Number: PAI VI (P6/38)
- Belgian National Fund for Scientific Research (FNRS), Joseph Maisin Foundation, Saint-Luc Foundation, 2011 ISMRM Seed Grant, EU FP7 Large Scale Integrating Project INMiND
- oxygen mapping;
- tissue hypoxia;
- endogenous contrast
Because of its paramagnetic properties, oxygen may act as an endogenous magnetic resonance imaging contrast agent by changing proton relaxation rates. Changes in tissue oxygen concentrations have been shown to produce changes in relaxation rate R1 of water. The aim of the study was to improve the sensitivity of oxygen enhanced R1 imaging by exploiting the higher solubility of oxygen in lipids (as compared with water) to sensitively monitor changes in tissue oxygen levels by selectively measuring the R1 of lipids.
The method, with the acronym “MOBILE” (mapping of oxygen by imaging lipids relaxation enhancement), was applied in different mouse models of hypoxic processes on a 11.7 T magnetic resonance imaging system. MOBILE was compared with R*2, R1 of water, and with pO2 measurements (using electron paramagnetic resonance oximetry). MOBILE was also applied in the brain of healthy human volunteers exposed to an oxygen breathing challenge on a 3 T magnetic resonance imaging system.
MOBILE was shown to be able to monitor changes in oxygenation in tumor, peripheral, liver, and brain tissues. The clinical translation was demonstrated in human volunteers.
MOBILE arises as a promising noninvasive and sensitive tool for diagnosis and therapeutic guidance in disorders involving hypoxia. Magn Reson Med 70:732–744, 2013. © 2012 Wiley Periodicals, Inc.