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Detection of radiation-induced lung injury using hyperpolarized 13C magnetic resonance spectroscopy and imaging

Authors

  • K. Thind,

    Corresponding author
    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    • Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada N6A 5K8. E-mail: kthind@imaging.robarts.ca

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  • A. Chen,

    1. GE Healthcare, Toronto, Ontario, Canada
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  • L. Friesen-Waldner,

    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
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  • A. Ouriadov,

    1. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
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  • T. J. Scholl,

    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
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  • M. Fox,

    1. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    2. Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada
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  • E. Wong,

    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    3. Department of Physics and Astronomy, University of Western Ontario, London, Ontario, Canada
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  • J. VanDyk,

    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Department of Oncology, University of Western Ontario, London, Ontario, Canada
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  • A. Hope,

    1. Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    2. Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
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  • G. Santyr

    1. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
    2. Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    3. Department of Medical Imaging, University of Western Ontario, London, Ontario, Canada
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Abstract

Radiation-induced lung injury limits radiotherapy of thoracic cancers. Detection of radiation pneumonitis associated with early radiation-induced lung injury (2–4 weeks postirradiation) may provide an opportunity to adjust treatment, before the onset of acute pneumonitis and/or irreversible fibrosis. In this study, localized magnetic resonance (MR) spectroscopy and imaging of hyperpolarized 13C-pyruvate (pyruvate) and 13C-lactate (lactate) were performed in the thorax and kidney regions of rats 2 weeks following whole-thorax irradiation (14 Gy). Lactate-to-pyruvate signal ratio was observed to increase by 110% (P < 0.01), 57% (P < 0.02), and 107% (P < 0.01), respectively, in the thorax, lung, and heart tissues of the radiated rats compared with healthy age-matched rats. This was consistent with lung inflammation confirmed using cell micrographs of bronchioalveolar lavage specimens and decreases in arterial oxygen partial pressure (paO2), indicative of hypoxia. No statistically significant difference was observed in either lactate-to-pyruvate signal ratios in the kidney region (P = 0.50) between the healthy (0.215 ± 0.100) and radiated cohorts (0.215 ± 0.054) or in blood lactate levels (P = 0.69) in the healthy (1.255 ± 0.247 mmol/L) and the radiated cohorts (1.325 ± 0.214 mmol/L), confirming that the injury is localized to the thorax. This work demonstrates the feasibility of hyperpolarized 13C metabolic MR spectroscopy and imaging for detection of early radiation-induced lung injury. Magn Reson Med 70:601–609, 2013. © 2012 Wiley Periodicals, Inc.

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