Multi-slice myelin water imaging for practical clinical applications at 3.0 T

Authors

  • Junyu Guo,

    Corresponding author
    1. Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
    • Correspondence to: Junyu Guo, Ph.D., Department of Radiological Sciences, Mail Stop 220, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678. E-mail: junyu.guo@stjude.org

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  • Qing Ji,

    1. Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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  • Wilburn E. Reddick

    1. Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
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Abstract

Myelin water imaging is a promising, noninvasive technique for evaluating white matter diseases such as multiple sclerosis and other leukoencephalopathies (LE), and monitoring myelination in early childhood. Unfortunately, poor image quality and a long acquisition time are major obstacles to practical clinical applications. In this study, a novel postprocessing method with an efficient multi-slice acquisition scheme, called T2 spectrum analysis using a weighted regularized non-negative least squares algorithm and nonlocal mean filter (T2SPARC), is presented to overcome these obstacles and achieve a shorter acquisition time, higher image quality, and large volume coverage. In vivo results from healthy volunteers and a patient with LE showed that the T2SPARC method can generate robust and high-quality myelin water fraction maps of 10 slices within 11 min. This method also yields some useful byproducts such as intra- and extracellular water fraction and long T2 tissue water fraction maps, which can quantify lesions in different brain diseases. Magn Reson Med 70:813–822, 2013. © 2012 Wiley Periodicals, Inc.

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