SEARCH

SEARCH BY CITATION

Keywords:

  • MR;
  • inline image;
  • liver;
  • tumor;
  • histopathology;
  • hypoxia;
  • metastasis;
  • colorectal;
  • cancer;
  • in vivo

In this study, the reproducibility of inline image MR imaging in colorectal liver metastases was assessed and inline image values were correlated with the expression of the hypoxia-related markers GLUT-1 and CA-IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of inline image was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median inline image of all liver metastases was 25.0 ± 5.6 ms vs. 23.0 ± 4.1 ms (median ± st.dev.) in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were −13.2 ms and 9.1 ms for median inline image values. On average, inline image showed fair reproducibility. No correlations between inline image values, hypoxia- and vascularity-related markers were observed. Magn Reson Med, 70:1145–1152, 2013. © 2012 Wiley Periodicals, Inc.