Reproducibility and biological basis of in vivo T2* magnetic resonance imaging of liver metastasis of colorectal cancer
Article first published online: 19 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 4, pages 1145–1152, October 2013
How to Cite
ter Voert, E. G. W., Heijmen, L., de Wilt, J. H. W., Bussink, J., Punt, C. J. A., van Laarhoven, H. W. M. and Heerschap, A. (2013), Reproducibility and biological basis of in vivo T2* magnetic resonance imaging of liver metastasis of colorectal cancer. Magn Reson Med, 70: 1145–1152. doi: 10.1002/mrm.24543
- Issue published online: 24 SEP 2013
- Article first published online: 19 NOV 2012
- Manuscript Accepted: 5 OCT 2012
- Manuscript Revised: 29 SEP 2012
- Manuscript Received: 7 JUL 2012
- Dutch Cancer Society (KWF Kankerbestrijding). Grant Number: KUN 2008-4098
- in vivo
In this study, the reproducibility of MR imaging in colorectal liver metastases was assessed and values were correlated with the expression of the hypoxia-related markers GLUT-1 and CA-IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median of all liver metastases was 25.0 ± 5.6 ms vs. 23.0 ± 4.1 ms (median ± st.dev.) in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were −13.2 ms and 9.1 ms for median values. On average, showed fair reproducibility. No correlations between values, hypoxia- and vascularity-related markers were observed. Magn Reson Med, 70:1145–1152, 2013. © 2012 Wiley Periodicals, Inc.