Reproducibility and biological basis of in vivo T2* magnetic resonance imaging of liver metastasis of colorectal cancer



In this study, the reproducibility of math formula MR imaging in colorectal liver metastases was assessed and math formula values were correlated with the expression of the hypoxia-related markers GLUT-1 and CA-IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of math formula was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median math formula of all liver metastases was 25.0 ± 5.6 ms vs. 23.0 ± 4.1 ms (median ± in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were −13.2 ms and 9.1 ms for median math formula values. On average, math formula showed fair reproducibility. No correlations between math formula values, hypoxia- and vascularity-related markers were observed. Magn Reson Med, 70:1145–1152, 2013. © 2012 Wiley Periodicals, Inc.