Motion and flow insensitive adiabatic T2-preparation module for cardiac MR imaging at 3 tesla

Authors

  • Elizabeth R. Jenista,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
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  • Wolfgang G. Rehwald,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
    2. Cardiovascular MR R&D, Siemens Healthcare, Chicago, Illinois, USA
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  • Enn-Ling Chen,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
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  • Han W. Kim,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
    2. Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
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  • Igor Klem,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
    2. Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
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  • Michele A. Parker,

    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
    2. Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
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  • Raymond J. Kim

    Corresponding author
    1. Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA
    2. Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    3. Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
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Abstract

A versatile method for generating T2-weighting is a T2-preparation module, which has been used successfully for cardiac imaging at 1.5T. Although it has been applied at 3T, higher fields (B0 ≥ 3T) can degrade B0 and B1 homogeneity and result in nonuniform magnetization preparation. For cardiac imaging, blood flow and cardiac motion may further impair magnetization preparation. In this study, a novel T2-preparation module containing multiple adiabatic B1-insensitive refocusing pulses is introduced and compared with three previously described modules [(a) composite MLEV4, (b) modified BIR-4 (mBIR-4), and (c) Silver-Hoult–pair]. In the static phantom, the proposed module provided similar or better B0 and B1 insensitivity than the other modules. In human subjects (n = 21), quantitative measurement of image signal coefficient of variation, reflecting overall image inhomogeneity, was lower for the proposed module (0.10) than for MLEV4 (0.15, P < 0.0001), mBIR-4 (0.27, P < 0.0001), and Silver-Hoult–pair (0.14, P = 0.001) modules. Similarly, qualitative analysis revealed that the proposed module had the best image quality scores and ranking (both, P < 0.0001). In conclusion, we present a new T2-preparation module, which is shown to be robust for cardiac imaging at 3T in comparison with existing methods. Magn Reson Med 70:1360–1368, 2013. © 2012 Wiley Periodicals, Inc.

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