Improved first-pass spiral myocardial perfusion imaging with variable density trajectories
Article first published online: 27 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 5, pages 1369–1379, November 2013
How to Cite
Salerno, M., Sica, C., Kramer, C. M. and Meyer, C. H. (2013), Improved first-pass spiral myocardial perfusion imaging with variable density trajectories. Magn Reson Med, 70: 1369–1379. doi: 10.1002/mrm.24569
- Issue published online: 25 OCT 2013
- Article first published online: 27 DEC 2012
- Manuscript Accepted: 27 OCT 2012
- Manuscript Revised: 25 OCT 2012
- Manuscript Received: 7 JUL 2012
- Siemens Medical Solutions. Grant Numbers: AHA 10SDG2650038, NIH R01 HL079110, NIH K23 HL112910-01
- myocardial perfusion;
- variable density spirals;
- spiral pulse sequences;
- saturation recovery
To develop and evaluate variable-density spiral first-pass perfusion pulse sequences for improved efficiency and off-resonance performance and to demonstrate the utility of an apodizing density compensation function (DCF) to improve signal-to-noise ratio (SNR) and reduce dark-rim artifact caused by cardiac motion and Gibbs Ringing.
Three variable density spiral trajectories were designed, simulated, and evaluated in 18 normal subjects, and in eight patients with cardiac pathology on a 1.5T scanner.
By using a DCF, which intentionally apodizes the k-space data, the sidelobe amplitude of the theoretical point spread function (PSF) is reduced by 68%, with only a 13% increase in the full-width at half-maximum of the main-lobe when compared with the same data corrected with a conventional variable-density DCF, and has an 8% higher resolution than a uniform density spiral with the same number of interleaves and readout duration. Furthermore, this strategy results in a greater than 60% increase in measured SNR when compared with the same variable-density spiral data corrected with a conventional DCF (P < 0.01). Perfusion defects could be clearly visualized with minimal off-resonance and dark-rim artifacts.
Variable-density spiral pulse sequences using an apodized DCF produce high-quality first-pass perfusion images with minimal dark-rim and off-resonance artifacts, high SNR and contrast-to-noise ratio, and good delineation of resting perfusion abnormalities. Magn Reson Med 70:1369–1379, 2013. © 2012 Wiley Periodicals, Inc.