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Diffusion-weighted 3D multislab echo planar imaging for high signal-to-noise ratio efficiency and isotropic image resolution

Authors

  • Mathias Engström,

    Corresponding author
    1. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    2. Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden
    • Correspondence to: Mathias Engström, M.Sc., Department of Neuroradiology, R3:00, Karolinska University Hospital, Stockholm SE-17176, Sweden. E-mail: mathias.engstrom@gmail.com

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  • Stefan Skare

    1. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    2. Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden
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Abstract

Purpose

To acquire isotropic high-resolution, signal-to-noise ratio (SNR) efficient, 3D encoded diffusion-weighted MRI data.

Methods

Multiple Fourier encoded slabs were combined into one full volume, using a generalized autocalibrating partially parallel acquisitions (GRAPPA) accelerated diffusion-weighted 3D multislab echo planar imaging (EPI) sequence with 2D phase navigation and in-plane motion correction.

Results

Reconstructed data with 1.5-mm3 nominal resolution is presented and shown under the influence of motion and with variable slab thicknesses. The SNR efficiency between diffusion-weighted 3D multislab EPI and DW 2D ss-EPI is compared. Finally, a 1.3-mm3 full brain scan with 45 diffusion directions is presented.

Conclusions

Diffusion-weighted 3D multislab EPI has been presented as an alternative sequence for high-resolution and high-SNR full brain coverage diffusion studies. Compared with the gold standard 2D diffusion-weighted single-shot Echo Planar Imaging, the SNR efficiency is significantly higher. Magn Reson Med 70:1507–1514, 2013. © 2013 Wiley Periodicals, Inc.

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