Novel retrospective, respiratory-gating method enables 3D, high resolution, dynamic imaging of the upper airway during tidal breathing
Article first published online: 7 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 6, pages 1580–1590, December 2013
How to Cite
Wagshul, M. E., Sin, S., Lipton, M. L., Shifteh, K. and Arens, R. (2013), Novel retrospective, respiratory-gating method enables 3D, high resolution, dynamic imaging of the upper airway during tidal breathing. Magn Reson Med, 70: 1580–1590. doi: 10.1002/mrm.24608
- Issue published online: 18 NOV 2013
- Article first published online: 7 FEB 2013
- Manuscript Accepted: 30 NOV 2012
- Manuscript Revised: 29 NOV 2012
- Manuscript Received: 24 JUL 2012
- NIH . Grant Numbers: HD-053693 , HL-105212
- Philips Medical Systems
- dynamic imaging;
- retrospective gating;
- sleep apnea;
- tidal volume;
- upper airway
A retrospective, respiratory-gated technique for measuring dynamic changes in the upper airway over the respiratory cycle was developed, with the ultimate goal of constructing anatomically and functionally accurate upper airway models in obstructive sleep apnea patients.
Three-dimensional cine, retrospective respiratory-gated, gradient echo imaging was performed in six adolescents being evaluated for polycystic ovary syndrome, a disorder with a high obstructive sleep apnea prevalence. A novel retrospective gating scheme, synchronized to flow from a nasal cannula, limited image acquisition to predefined physiological ranges. Images were evaluated with respect to contrast, airway signal leakage, and demonstration of dynamic airway area changes.
Two patients were diagnosed with obstructive sleep apnea. Motion artifacts were absent in all image sets. Scan efficiency ranged from 48 to 88%. Soft tissue-to-airway contrast-to-noise ratio varied from 6.1 to 9.6. Airway signal leakage varied between 10 and 17% of soft tissue signal. Automated segmentation allowed calculation of airway area changes over the respiratory cycle. In one severe apnea patient, the technique allowed demonstration of asynchronous airway expansion and contraction above and below a severe constriction.
Retrospective, respiratory gated imaging of the upper airway has been demonstrated, utilizing a gating algorithm to ensure acquisition over specified ranges of respiratory rate and tidal volume. Magn Reson Med 70:1580–1590, 2013. © 2013 Wiley Periodicals, Inc.