Dynamic imaging of the fetal heart using metric optimized gating
Article first published online: 4 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 6, pages 1598–1607, December 2013
How to Cite
Roy, C. W., Seed, M., van Amerom, J. F. P., Al Nafisi, B., Grosse-Wortmann, L., Yoo, S.-J. and Macgowan, C. K. (2013), Dynamic imaging of the fetal heart using metric optimized gating. Magn Reson Med, 70: 1598–1607. doi: 10.1002/mrm.24614
- Issue published online: 18 NOV 2013
- Article first published online: 4 FEB 2013
- Manuscript Accepted: 3 DEC 2012
- Manuscript Revised: 28 NOV 2012
- Manuscript Received: 15 JUL 2012
- Ontario Opportunity Trust Fund—Hospital for Sick Children Foundation Student Scholarship Program and Alexander Graham Bell Canada Graduate Scholarship (Natural Sciences and Engineering Research Council of Canada)
- fetal magnetic resonance imaging;
- image metric;
Advances in fetal cardiovascular magnetic resonance imaging have been limited by the absence of a reliable cardiac gating signal. The purpose of this work was to develop and validate metric-optimized gating (MOG) for cine imaging of the fetal heart.
Theory and Methods
Cine MR and electrocardiogram data were acquired in healthy adult volunteers for validation of the MOG method. Comparison of MOG and electrocardiogram reconstructions was performed based on the image quality for each method, and the difference between MOG and electrocardiogram trigger times. Fetal images were also acquired, their quality evaluated by experienced radiologists, and the theoretical error in the MOG trigger times were calculated.
Excellent agreement between electrocardiogram and MOG reconstructions was observed. The experimental errors in adult MOG trigger times for all five volunteers were ± (7, 25, 17, 8, and 13) ms. Fetal images captured normal and diseased cardiac dynamics.
MOG for cine imaging of the fetal myocardium was developed and validated in adults. Using MOG, the first gated MR images of the human fetal myocardium were obtained. Small moving structures were visualized during radial contraction, thus capturing normal fetal cardiac wall motion and permitting assessment of cardiac function. Magn Reson Med 70:1598–1607, 2013. © 2013 Wiley Periodicals, Inc.