Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI
Article first published online: 6 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 6, pages 1634–1643, December 2013
How to Cite
Holland, D. J., Liu, C., Song, X., Mazerolle, E. L., Stevens, M. T., Sederman, A. J., Gladden, L. F., D'Arcy, R. C. N., Bowen, C. V. and Beyea, S. D. (2013), Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI. Magn Reson Med, 70: 1634–1643. doi: 10.1002/mrm.24621
- Issue published online: 18 NOV 2013
- Article first published online: 6 FEB 2013
- Manuscript Accepted: 11 DEC 2012
- Manuscript Revised: 30 NOV 2012
- Manuscript Received: 11 JUN 2012
- EPSRC . Grant Number: EP/F047991/1
- NSERC Discovery Program
- Microsoft Research Connections
- compressed sensing;
Functional MRI (fMRI) techniques that can provide excellent blood oxygen level dependent contrast, rapid whole brain imaging, and minimal spatial distortion are in demand. This study explored whether fMRI sensitivity can be improved through the use of compressed sensing (CS) reconstruction of variable density spiral fMRI.
Three different CS-reconstructed 1-shot variable density spirals were explored (corresponding to 28%, 35%, and 46% under-sampling), and compared with conventional 1-shot and 2-shot Archimedean spirals acquired using matched echo time and volume repetition time. fMRI maps were reconstructed with or without CS MRI and sensitivity was compared using identically matched voxels.
The results demonstrated that an l1-norm based CS reconstruction only led to an increase in functional contrast when applied to 28% under-sampled data. A whole brain t-contrast map revealed that 2-shot uniformly sampled spiral and 28% under-sampled spiral data reconstructed with CS yield equivalent sensitivity, even with matched echo time and volume repetition time
VD spiral exhibits a useful operating range, in the region of 25–30% under-sampling, for which CS reconstruction can be used to increase the sensitivity of fMRI to brain activity. Using CS, VD acquisitions achieve the same sensitivity as 2-shot Archimedean acquisitions, but require only a single shot. Magn Reson Med 70:1634–1643, 2013. © 2013 Wiley Periodicals, Inc.