Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI

Authors

  • D. J. Holland,

    1. Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
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  • C. Liu,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
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  • X. Song,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
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  • E. L. Mazerolle,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
    2. Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada
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  • M. T. Stevens,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
    2. Department of Physics, Dalhousie University, Halifax, Nova Scotia, Canada
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  • A. J. Sederman,

    1. Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
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  • L. F. Gladden,

    1. Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
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  • R. C. N. D'Arcy,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
    2. Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada
    3. Department of Radiology, Dalhousie University, Halifax, Nova Scotia, Canada
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  • C. V. Bowen,

    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
    2. Department of Physics, Dalhousie University, Halifax, Nova Scotia, Canada
    3. Department of Radiology, Dalhousie University, Halifax, Nova Scotia, Canada
    4. School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada
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  • S. D. Beyea

    Corresponding author
    1. Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
    2. Department of Physics, Dalhousie University, Halifax, Nova Scotia, Canada
    3. Department of Radiology, Dalhousie University, Halifax, Nova Scotia, Canada
    4. School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada
    • Correspondence to: S. D. Beyea, Ph.D., Neuroimaging Research Lab, Suite 3900, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada B3H 5A7. E-mail: steven.beyea@dal.ca

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Abstract

Purpose

Functional MRI (fMRI) techniques that can provide excellent blood oxygen level dependent contrast, rapid whole brain imaging, and minimal spatial distortion are in demand. This study explored whether fMRI sensitivity can be improved through the use of compressed sensing (CS) reconstruction of variable density spiral fMRI.

Methods

Three different CS-reconstructed 1-shot variable density spirals were explored (corresponding to 28%, 35%, and 46% under-sampling), and compared with conventional 1-shot and 2-shot Archimedean spirals acquired using matched echo time and volume repetition time. fMRI maps were reconstructed with or without CS MRI and sensitivity was compared using identically matched voxels.

Results

The results demonstrated that an l1-norm based CS reconstruction only led to an increase in functional contrast when applied to 28% under-sampled data. A whole brain t-contrast map revealed that 2-shot uniformly sampled spiral and 28% under-sampled spiral data reconstructed with CS yield equivalent sensitivity, even with matched echo time and volume repetition time

Conclusion

VD spiral exhibits a useful operating range, in the region of 25–30% under-sampling, for which CS reconstruction can be used to increase the sensitivity of fMRI to brain activity. Using CS, VD acquisitions achieve the same sensitivity as 2-shot Archimedean acquisitions, but require only a single shot. Magn Reson Med 70:1634–1643, 2013. © 2013 Wiley Periodicals, Inc.

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