In vivo diffusion-weighted MRI using perfluorinated gases: ADC comparison between healthy and elastase-treated rat lungs
Version of Record online: 14 FEB 2013
Copyright © 2012 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 70, Issue 6, pages 1761–1764, December 2013
How to Cite
Carrero-González, L., Kaulisch, T. and Stiller, D. (2013), In vivo diffusion-weighted MRI using perfluorinated gases: ADC comparison between healthy and elastase-treated rat lungs. Magn Reson Med, 70: 1761–1764. doi: 10.1002/mrm.24627
- Issue online: 18 NOV 2013
- Version of Record online: 14 FEB 2013
- Manuscript Accepted: 14 DEC 2012
- Manuscript Revised: 7 DEC 2012
- Manuscript Received: 1 OCT 2012
- Marie-Curie training network MRTN-CT-2006-03602 (PHeLINet)
- in vivo small animals imaging;
MRI with perfluorinated gases has been shown as an alternative to hyperpolarized gases to image both microstructure and gas diffusivity in the lung. The aim of this study was to measure diffusion restriction of C2F6 in rat lungs and to compare the different levels of restriction between healthy and emphysematous tissue.
For this purpose, two groups of rats—healthy and mono-lobar elastase-induced animals—were measured. While being ventilated with a mixture of C2F6 and oxygen four diffusion weighted 19F-images where acquired for each animal and corresponding ADC-maps were calculated.
No significant apparent diffusion coefficient (ADC) differences were found between healthy lungs; however, the elastase treated lungs showed a significant increase in ADC.
These results demonstrate that ADC measurements with C2F6 are sensitive to the microstructure of rat lungs showing that the diffusion of this gas is limited to different levels in healthy and in emphysematous tissue. Magn Reson Med 70:1761–1764, 2013. © 2013 Wiley Periodicals, Inc.