4D Dark Blood Arterial Wall Magnetic Resonance Imaging: Methodology and Demonstration in the Carotid Arteries
Version of Record online: 11 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 69, Issue 4, pages 956–965, April 2013
How to Cite
Koktzoglou, I. (2013), 4D Dark Blood Arterial Wall Magnetic Resonance Imaging: Methodology and Demonstration in the Carotid Arteries. Magn Reson Med, 69: 956–965. doi: 10.1002/mrm.24647
- Issue online: 20 MAR 2013
- Version of Record online: 11 FEB 2013
- Manuscript Accepted: 2 JAN 2013
- Manuscript Revised: 6 DEC 2012
- Manuscript Received: 22 AUG 2012
- American Heart Association. Grant Number: SDG 0835367N
- arterial wall imaging;
- dark blood;
- carotid arteries
To propose and test a four-dimensional (4D) dark-blood magnetic resonance imaging (MRI) method based on a radial sampling trajectory capable of displaying the human arterial wall and its motion in three spatial dimensions over the cardiac cycle.
The carotid arteries of volunteer and patient subjects were imaged with the proposed 4D dark-blood MRI sequence on a 3T scanner. Validation of arterial lumen and arterial wall areas obtained with the proposed 4D dark-blood technique was made with respect to established two-dimensional bright-blood cine and high spatial resolution three-dimensional dark-blood MRI protocols, respectively.
The proposed 4D MRI method provided for dark-blood display of the carotid arterial wall and demonstrated its movement and distension over the cardiac cycle. Quantitative measurements of arterial lumen and wall areas were in statistical agreement with established MRI techniques.
4D blood suppressed MRI of the human vascular system with submillimeter isotropic spatial resolution is feasible in a clinically reasonable scan time, and data obtained in the carotid arteries show good agreement with established MRI techniques. Future efforts will examine the constellation of data provided by the method and investigate its utility for assessing cardiovascular risk. Magn Reson Med 69:956–965, 2013. © 2013 Wiley Periodicals, Inc.