Knee cartilage MRI with in situ mechanical loading using prospective motion correction
Article first published online: 25 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 71, Issue 2, pages 516–523, February 2014
How to Cite
Lange, T., Maclaren, J., Herbst, M., Lovell-Smith, C., Izadpanah, K. and Zaitsev, M. (2014), Knee cartilage MRI with in situ mechanical loading using prospective motion correction. Magn Reson Med, 71: 516–523. doi: 10.1002/mrm.24679
- Issue published online: 13 JAN 2014
- Article first published online: 25 FEB 2013
- Manuscript Accepted: 12 JAN 2013
- Manuscript Revised: 20 DEC 2012
- Manuscript Received: 23 NOV 2012
- German Federal Ministry of Education and Research (part of the INUMAC project) . Grant Number: 01EQ0605
- NIH/NIDA . Grant Number: 1R01 DA021146
- prospective motion correction;
- in situ mechanical loading
To assess the feasibility of high resolution knee cartilage MRI with in situ mechanical loading using optical tracking to compensate for motion.
In vivo cartilage MRI with in situ mechanical loading is demonstrated on a clinical 3T system for the patellofemoral as well as for the tibiofemoral knee joint using a T1-weighted spoiled three-dimensional gradient-echo sequence. Prospective motion correction is performed with a moiré phase tracking system consisting of an in-bore camera and a single tracking marker attached to the skin.
Rigid-body approximation required for prospective correction with optical motion tracking is fulfilled well enough for the patellofemoral as well as for the tibiofemoral joint when the tracking marker is attached to the knee cap and the shin, respectively. Presaturation proves to be efficient in suppressing pulsation artifacts from the popliteal artery and residual motion artifacts primarily arising from nonrigid motion of the posterior knee compartment.
The proposed technique enables knee cartilage imaging under in situ mechanical loading with submillimeter spatial resolution devoid of significant motion artifacts and thus appropriate for cartilage volumetry. It has the potential to provide new insight into the biomechanics of the knee and might complement the panoply of diagnostic MR methods for osteoarthritis. Magn Reson Med 71:516–523, 2014. © 2013 Wiley Periodicals, Inc.