Renal perfusion imaging with two-dimensional navigator gated arterial spin labeling
Version of Record online: 27 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 71, Issue 2, pages 570–579, February 2014
How to Cite
Tan, H., Koktzoglou, I. and Prasad, P. V. (2014), Renal perfusion imaging with two-dimensional navigator gated arterial spin labeling. Magn Reson Med, 71: 570–579. doi: 10.1002/mrm.24692
- Issue online: 13 JAN 2014
- Version of Record online: 27 FEB 2013
- Manuscript Accepted: 24 JAN 2013
- Manuscript Revised: 9 JAN 2013
- Manuscript Received: 4 DEC 2012
- NIH . Grant Numbers: R21DK079080 , R01DK093793
- AHA . Grant Number: SDG0835367N
- 2D navigator;
- renal perfusion;
- FAIR True-FISP;
- respiratory motion
To develop a navigator technique enabling free-breathing acquisition to afford sufficient signal averaging for quantitative renal perfusion measurement using arterial spin labeling MRI.
A novel two-dimensional (2D) navigator technique was implemented in concert with flow-sensitive alternating inversion recovery (FAIR) preparation and true fast imaging with steady precession (True-FISP) readout. The navigator images were obtained with a low-resolution fast low angle shot readout at end of each arterial spin labeling acquisition. A retrospective algorithm was developed to automatically detect respiratory motion for selective signal averaging. The 2D navigator-gated FAIR True-FISP sequence was performed in ten healthy volunteers and five patients with chronic kidney disease.
Excellent image quality and comparable cortical perfusion rates (healthy: 276 ± 28 mL/100 g/min, patients: 155 ± 25 mL/100 g/min) to literature values were obtained. An average of 3-fold signal-to-noise ratio improvement was obtained in the 2D navigator-gated approach compared with the breath-hold acquisition in healthy volunteers. Good image quality was achieved in patients while the results from breath-hold acquisition were unusable. The quantitative perfusion rates were significantly lower in chronic kidney disease patients compared with the healthy volunteers.
2D navigator-gated free breathing arterial spin labeling is feasible and is a noninvasive method to evaluate renal perfusion both in healthy subjects and those with chronic kidney disease. Magn Reson Med 71:570–579, 2014. © 2013 Wiley Periodicals, Inc.