Intramolecular zero-quantum-coherence 2D NMR spectroscopy of lipids in the human breast at 7 T
Article first published online: 6 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 71, Issue 2, pages 451–457, February 2014
How to Cite
de Graaf, R. A., Klomp, D. W. J., Luijten, P. R. and Boer, V. O. (2014), Intramolecular zero-quantum-coherence 2D NMR spectroscopy of lipids in the human breast at 7 T. Magn Reson Med, 71: 451–457. doi: 10.1002/mrm.24701
- Issue published online: 13 JAN 2014
- Article first published online: 6 MAR 2013
- Manuscript Accepted: 31 JAN 2013
- Manuscript Received: 24 DEC 2012
- Manuscript Revised: 24 DEC 2012
- human breast;
- unsaturated fatty acids;
- magnetic field inhomogeneity;
- 7 Tesla
Intramolecular zero-quantum-coherences (ZQCs) are intrinsically insensitive toward magnetic field inhomogeneity. This fact is used to quantify and characterize lipid signals in the human breast at 7 T despite the presence of severe magnetic field inhomogeneity caused by water–lipid susceptibility boundaries.
A novel 3D localized 2D ZQC method is presented. The combination of cardiac/respiratory triggering and post-acquisition navigator echo correction provides high-quality 2D NMR spectra in vivo.
The lipid profile of the human breast could be quantified by 2D ZQC NMR in 100% of the subjects despite a wide range of magnetic field homogeneity. With conventional 1D 1H MRS, the magnetic field homogeneity was only adequate in 60% of the subjects. The results from 2D ZQC NMR and 1D NMR are in good correspondence, both in vitro and in vivo.
It has been demonstrated that high quality and quantitative 2D ZQC NMR spectra can be acquired from human breast tissue at 7 T. While the simplicity and sensitivity of 1D MRS are preferable when the magnetic field homogeneity is adequate, the 2D ZQC method provides a viable alternative in cases where this requirement cannot be met. Magn Reson Med 71:451–457, 2014. © 2013 Wiley Periodicals, Inc.