Article first published online: 8 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 71, Issue 2, pages 458–468, February 2014
How to Cite
Fuchs, A., Boesiger, P., Schulte, R. F. and Henning, A. (2014), ProFit revisited. Magn Reson Med, 71: 458–468. doi: 10.1002/mrm.24703
- Issue published online: 13 JAN 2014
- Article first published online: 8 MAR 2013
- Manuscript Accepted: 5 FEB 2013
- Manuscript Revised: 12 JAN 2013
- Manuscript Received: 6 NOV 2012
- spectral fitting;
- 2D JPRESS;
- prior knowledge model fitting;
- 2D J-resolved spectroscopy;
- 2D macromolecular baseline
An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data.
The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured macromolecular baseline contribution, additional baseline splines and a model-free lineshape based on self-deconvolution. The new software was tested and tuned on simulated data and subsequently applied to in vivo intrasubject and intersubject data.
Fit results of simulated and acquired spectra show good overall quality suggesting the potential reliable detection of up to 18 metabolites on a 3T system yielding Cramer-Lower-Bounds below 20%.
The proposed enhanced version of ProFit together with two-dimensional J-resolved spectroscopy offers the opportunity to reliably detect a wide selection of important brain metabolites on 3T. Magn Reson Med 71:458–468, 2014. © 2013 Wiley Periodicals, Inc.