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APT-weighted and NOE-weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses

Authors

  • Jinyuan Zhou,

    Corresponding author
    1. F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
    • Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
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  • Xiaohua Hong,

    1. Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
    2. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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  • Xuna Zhao,

    1. Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China
    2. Philips Healthcare, IGIT, Beijing, China
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  • Jia-Hong Gao,

    1. Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China
    2. Brain Research Imaging Center, University of Chicago, Chicago, Illinois, USA
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  • Jing Yuan

    1. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
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Correspondence to: Jinyuan Zhou, Ph.D., Division of MR Research, Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Park 336, Baltimore, MD 21287. E-mail: jzhou@mri.jhu.edu

Abstract

Purpose

To investigate the saturation-power dependence of amide proton transfer (APT)-weighted and nuclear Overhauser enhancement-weighted image contrasts in a rat glioma model at 4.7 T.

Methods

The 9L tumor-bearing rats (n = 8) and fresh chicken eggs (n = 4) were scanned on a 4.7-T animal magnetic resonance imaging scanner. Z-spectra over an offset range of ±6 ppm were acquired with different saturation powers, followed by the magnetization transfer-ratio asymmetry analyses around the water resonance.

Results

The nuclear Overhauser enhancement signal upfield from the water resonance (−2.5 to −5 ppm) was clearly visible at lower saturation powers (e.g., 0.6 µT) and was larger in the contralateral normal brain tissue than in the tumor. Conversely, the APT effect downfield from the water resonance was maximized at relatively higher saturation powers (e.g., 2.1 µT) and was larger in the tumor than in the contralateral normal brain tissue. The nuclear Overhauser enhancement decreased the APT-weighted image signal, based on the magnetization transfer-ratio asymmetry analysis, but increased the APT-weighted image contrast between the tumor and contralateral normal brain tissue.

Conclusion

The APT and nuclear Overhauser enhancement image signals in tumor are maximized at different saturation powers. The saturation power of roughly 2 μT is ideal for APT-weighted imaging at clinical B0 field strengths. Magn Reson Med 70:320–327, 2013. © 2013 Wiley Periodicals, Inc.

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