Quantification of human lung structure and physiology using hyperpolarized 129Xe
Version of Record online: 23 OCT 2013
Copyright © 2013 Wiley Periodicals, Inc.
Magnetic Resonance in Medicine
Volume 71, Issue 1, pages 339–344, January 2014
How to Cite
Chang, Y. V., Quirk, J. D., Ruset, I. C., Atkinson, J. J., Hersman, F. W. and Woods, J. C. (2014), Quantification of human lung structure and physiology using hyperpolarized 129Xe. Magn Reson Med, 71: 339–344. doi: 10.1002/mrm.24992
- Issue online: 17 DEC 2013
- Version of Record online: 23 OCT 2013
- Manuscript Accepted: 17 SEP 2013
- Manuscript Revised: 13 SEP 2013
- Manuscript Received: 13 JUN 2013
- National Heart, Lung, and Blood Institute . Grant Numbers: HL087550 , HL090806 , R44HL112397
- Mallinckrodt Institute of Radiology, Washington University School of Medicine (Y.V.C.)
- lung physiology;
- barrier thickness;
- surface-area-to-volume ratio;
- Fahraeus effect;
- field-dependent chemical shift
To present in vivo, human validation of a previously proposed method to measure key pulmonary parameters related to lung microstructure and physiology. Some parameters, such as blood–air barrier thickness, cannot be measured readily by any other noninvasive modality.
Healthy volunteers (n = 12) were studied in 1.5T and 3T whole body human scanners using hyperpolarized xenon. Xenon uptake by lung parenchyma and blood was measured using a chemical shift saturation recovery sequence. Both dissolved-xenon peaks at 197 ppm and 217–218 ppm were fitted against a model of xenon exchange (MOXE) as functions of exchange time. Parameters related to lung function and structure can be obtained by fitting to this model.
The following results were obtained from xenon uptake (averaged over all healthy volunteers): surface-area-to-volume ratio = 210 ± 50 cm−1; total septal wall thickness = 9.2 ± 6.5 μm; blood-air barrier thickness = 1.0 ± 0.3 μm; hematocrit = 27 ± 4%; pulmonary capillary blood transit time = 1.3 ± 0.3 s, in good agreement with literature values from invasive experiments. More detailed fitting results are listed in the text.
The initial in vivo human results demonstrate that our proposed methods can be used to noninvasively determine lung physiology by simultaneous quantification of a few important pulmonary parameters. This method is highly promising to become a versatile screening method for lung diseases. Magn Reson Med 71:339–344, 2014. © 2013 Wiley Periodicals, Inc.