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Hyperpolarized H2O MR angiography

Authors

  • Jan H. Ardenkjaer-Larsen,

    Corresponding author
    1. Technical University of Denmark, Kgs Lyngby, Denmark
    2. Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark
    3. GE Healthcare, Broendby, Denmark
    • Correspondence to: Jan H. Ardenkjaer-Larsen, Ph.D., Technical University of Denmark, Orsted Plads 349/106, 2800 Kgs Lyngby, Denmark.

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  • Christoffer Laustsen,

    1. Danish Research Center for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark
    2. The MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark
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  • Sean Bowen,

    1. Technical University of Denmark, Kgs Lyngby, Denmark
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  • Rahim Rizi

    1. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Abstract

Purpose

The aim of this study was to demonstrate that dissolution- dynamic nuclear polarization is capable of hyperpolarizing water protons and that the signal from the hyperpolarized bolus injection can be exploited in angiographic applications.

Methods

We hyperpolarized water/glycerol using dynamic nuclear polarization followed by dissolution in D2O.

Results

A water 1H signal enhancement of 77 times compared with 4.7 Tesla was obtained. This corresponds to a polarization of 3.5% for the 3.9 mol/L 1H in D2O . Moreover, a T1 in excess of 20 s was achieved.

Conclusion

The use of hyperpolarized water as a contrast agent presents a new opportunity to obtain MRA images with high contrast-to-noise in a fraction of a second. Magn Reson Med 71:50–56, 2014. © 2013 Wiley Periodicals, Inc.

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