Simultaneous multislice accelerated interleaved EPI DWI using generalized blipped-CAIPI acquisition and 3D K-space reconstruction

Authors

  • Erpeng Dai,

    1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China
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  • Xiaodong Ma,

    1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China
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  • Zhe Zhang,

    1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China
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  • Chun Yuan,

    1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China
    2. Department of Radiology, University of Washington, Seattle, WA, USA
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  • Hua Guo

    Corresponding author
    1. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China
    • Correspondence to: Hua Guo, PhD, Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. Telephone: +86-10-6279-5886; E-mail: huaguo@tsinghua.edu.cn

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Abstract

Purpose

Simultaneous multislice (SMS) has been proved to be powerful for accelerating single-shot echo-planar imaging (ssh-EPI) based diffusion-weighted imaging (DWI), but there are some obstacles for applying SMS to interleaved echo-planar imaging (iEPI) DWI. The primary challenge is to effectively combine slice unfolding for SMS and intershot phase correction for multishot DWI. In this study, a novel acquisition and reconstruction method for SMS-accelerated high-resolution iEPI DWI is proposed.

Theory and Methods

The traditional blipped-controlled aliasing in parallel imaging (blipped-CAIPI) for ssh-EPI is generalized for iEPI acquisitions. An SMS three-dimensional (3D) navigator acquisition is designed to record the intershot phase variations. Then, slice unfolding and intershot phase correction are performed simultaneously in an SMS 3D k-space. The performance of the proposed method is demonstrated in both four-shot and eight-shot iEPI DWI and compared with ssh-EPI and unaccelerated iEPI DWI.

Results

The proposed method successfully unfolded the simultaneously excited slices and effectively suppressed artifacts from intershot phase variations. The SMS-accelerated iEPI improved the imaging efficiency, while preserving comparable image quality as unaccelerated iEPI DWI.

Conclusions

The proposed acquisition and reconstruction is an effective method for accelerating multishot high-resolution DWI, which may be valuable for both neuroscience research and clinical diagnosis. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

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