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Molecular Systems Biology

Cover image for Vol. 10 Issue 6

June 2014

Volume 10, Issue 6

  1. Articles

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    2. Articles
    1. You have full text access to this OnlineOpen article
      Cell cycle population effects in perturbation studies

      Eoghan O'Duibhir, Philip Lijnzaad, Joris J Benschop, Tineke L Lenstra, Dik van Leenen, Marian JA Groot Koerkamp, Thanasis Margaritis, Mariel O Brok, Patrick Kemmeren and Frank CP Holstege

      Version of Record online: 25 JUN 2014 | DOI: 10.15252/msb.20145172

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      Genetic, stress or nutrient perturbation of yeast resulting in slower growth yields a common expression signature, previously known as the environmental stress response. This is largely due to a cell cycle population shift and is relevant to many perturbation-based studies.

    2. You have full text access to this OnlineOpen article
      Efficient search, mapping, and optimization of multi-protein genetic systems in diverse bacteria

      Iman Farasat, Manish Kushwaha, Jason Collens, Michael Easterbrook, Matthew Guido and Howard M Salis

      Version of Record online: 25 JUN 2014 | DOI: 10.15252/msb.20134955

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      A computational approach for designing multi-enzyme pathways is presented that combines sequence optimization, kinetic modeling, and accurate expression prediction. The method is illustrated for the direct forward engineering of robust circuits with targeted activities.

    3. You have full text access to this OnlineOpen article
      Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

      Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour and Howard T Jacobs

      Version of Record online: 25 JUN 2014 | DOI: 10.15252/msb.20145117

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      An RNAi screen for genes needed in mtDNA copy number maintenance in Drosophila yielded 97 positives, including previously characterized mtDNA maintenance proteins, subunits of the cytoribosome, proteasome, and ATP synthase.

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