Immunologic Aspects of Multiple Sclerosis

Authors

  • Sridhar Boppana PhD,

    1. Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ
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  • Hui Huang MD, PhD,

    1. Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ
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  • Kouichi Ito PhD,

    1. Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ
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  • Suhayl Dhib-Jalbut MD

    Corresponding author
    1. Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ
    • Department of Neurology University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School Piscataway, NJ
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Abstract

Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system characterized by demyelination and axonal loss. Genetic and environmental factors contribute to the risk of immune dysregulation in multiple sclerosis. The review focuses on the immunopathogenic role played by various lymphocyte subsets and their cytokine products in the onset and disease progression, and the role of regulatory immune cells in disease remission. The mechanism of action of approved and experimental therapies, and how these mechanisms support the immunopathogenesis paradigm, is also reviewed. Mt Sinai J Med 78:207–220, 2011. © 2011 Mount Sinai School of Medicine

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