Research Article

Running endurance abnormality in mdx mice

  1. Hajime Hara MD, PhD1,*,
  2. Patrick M. Nolan PhD2,
  3. Marion O. Scott3,
  4. Maja Bucan PhD2,
  5. Yoshihiro Wakayama MD, PhD1,
  6. Kenneth H. Fischbeck MD4

Article first published online: 28 JAN 2002

DOI: 10.1002/mus.10023

Issue

Muscle & Nerve

Muscle & Nerve

Volume 25, Issue 2, pages 207–211, February 2002

Additional Information

How to Cite

Hara, H., Nolan, P. M., Scott, M. O., Bucan, M., Wakayama, Y. and Fischbeck, K. H. (2002), Running endurance abnormality in mdx mice. Muscle Nerve, 25: 207–211. doi: 10.1002/mus.10023

Author Information

  1. 1

    Division of Neurology, Department of Medicine, Showa University, Fujigaoka Hospital, 1-30, Fujigaoka, Aobaku, Yokohamashi 227-0043, Japan

  2. 2

    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

  3. 3

    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

  4. 4

    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

*Division of Neurology, Department of Medicine, Showa University, Fujigaoka Hospital, 1-30, Fujigaoka, Aobaku, Yokohamashi 227-0043, Japan

Publication History

  1. Issue published online: 28 JAN 2002
  2. Article first published online: 28 JAN 2002
  3. Manuscript Accepted: 31 AUG 2001

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Keywords:

  • Duchenne muscular dystrophy;
  • dystrophin;
  • mdx mouse;
  • phenotype analysis;
  • running wheel

Abstract

The mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contrast to the continuous running seen in controls. The average continuous running time differed significantly between mdx and control mice at all ages tested (5–21 weeks). This assay is noninvasive, has the advantage of unbiased automatic data collection, and should be useful for quantifying the mdx deficit in therapeutic studies. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 207–211, 2002 DOI 10.1002/mus.10021

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