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Heat shock proteins and neuromuscular disease

Authors

  • Robert N. Nishimura MD,

    Corresponding author
    1. Department of Neurology, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
    2. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    • Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
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  • Frank R. Sharp MD

    1. Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute and Department of Neurology, University of California at Davis, Sacramento, California, USA
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Abstract

The heat shock proteins are families of proteins with known activities that include chaperoning nascent peptides within the cell and cytoprotection. Most work on the nervous system has related to the role of heat shock proteins in neuroprotection from either hypoxic-ischemic or traumatic injury. The role of these proteins during normal physiological activity and injury is still under investigation. Heat shock proteins in neuromuscular disease have been investigated to some extent but were largely neglected until recently. The goal of this review is to summarize the evidence linking heat shock proteins with neuromuscular disease and to provide some insight into the roles or functions of these proteins in disease states. Muscle Nerve, 2005

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