Assessment of regional body composition with dual-energy X-ray absorptiometry in Duchenne muscular dystrophy: Correlation of regional lean mass and quantitative strength

Authors

  • Andrew J. Skalsky MD,

    Corresponding author
    1. Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
    2. NIDRR Rehabilitation Research and Training Center in Neuromuscular Diseases, University of California, Davis, Davis, California, USA
    • Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
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  • Jay J. Han MD,

    1. Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
    2. NIDRR Rehabilitation Research and Training Center in Neuromuscular Diseases, University of California, Davis, Davis, California, USA
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  • Richard T. Abresch MS,

    1. Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
    2. NIDRR Rehabilitation Research and Training Center in Neuromuscular Diseases, University of California, Davis, Davis, California, USA
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  • Chris S. Shin MD,

    1. Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
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  • Craig M. McDonald MD

    1. Department of Physical Medicine and Rehabilitation, University of California, Davis, 4860 Y Street, Suite 3850, Sacramento, California 95817, USA
    2. NIDRR Rehabilitation Research and Training Center in Neuromuscular Diseases, University of California, Davis, Davis, California, USA
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Abstract

The purpose of this study was to assess regional body composition and its correlation with regional strength in Duchenne muscular dystrophy (DMD) subjects and able-bodied controls. Regional dual-energy X-ray absorptiometry (DEXA) measurements and isometric strength were obtained for 23 DMD subjects and 23 control subjects. DMD subjects showed a decreased regional lean mass (P < 0.001). The correlation between regional strength and regional lean mass was stronger for controls than for DMD subjects. DMD subjects had decreased regional lean mass, increased regional fat mass, and decreased strength. Muscle Nerve 39: 647–651, 2009

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