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Diagnostic nerve ultrasound in Charcot–Marie–Tooth disease type 1B

Authors

  • Michael S. Cartwright MD,

    Corresponding author
    1. Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Meads Hall, Winston-Salem, North Carolina 27157, USA
    2. Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    3. Department of Neurology, Ohio State University College of Medicine, Columbus, Ohio, USA
    • Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Meads Hall, Winston-Salem, North Carolina 27157, USA
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  • Martin E. Brown MD,

    1. Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky, USA
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  • Patrick Eulitt BS,

    1. Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Meads Hall, Winston-Salem, North Carolina 27157, USA
    2. Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    3. Department of Neurology, Ohio State University College of Medicine, Columbus, Ohio, USA
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  • Francis O. Walker MD,

    1. Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Meads Hall, Winston-Salem, North Carolina 27157, USA
    2. Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    3. Department of Neurology, Ohio State University College of Medicine, Columbus, Ohio, USA
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  • Victoria H. Lawson MD,

    1. Department of Neurology, Ohio State University College of Medicine, Columbus, Ohio, USA
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  • James B. Caress MD

    1. Department of Neurology, Wake Forest University School of Medicine, Medical Center Boulevard, Meads Hall, Winston-Salem, North Carolina 27157, USA
    2. Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    3. Department of Neurology, Ohio State University College of Medicine, Columbus, Ohio, USA
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Errata

This article is corrected by:

  1. Errata: Erratum Volume 51, Issue 6, 940, Article first published online: 14 May 2015

Abstract

Ultrasound is emerging as a useful tool for evaluation of neuromuscular conditions, because it can provide high-resolution anatomic information to complement electrodiagnostic data. There have been few studies in which ultrasound was used to assess the peripheral nerves of individuals with Charcot–Marie–Tooth (CMT) disease and none involving CMT type 1B. In this study we compared nerve cross-sectional area in individuals from a single large family with CMT 1B with normal, healthy controls. We also assessed for cranial nerve enlargement in those with CMT 1B with cranial neuropathies compared to those with CMT 1B without cranial neuropathies. Individuals with CMT 1B have significantly larger median and vagus nerves than healthy controls, but no difference was seen in cranial nerve size between those with versus those without cranial neuropathies. This is the first study to characterize the ultrasonographic findings in the peripheral nerves of individuals with CMT 1B. Muscle Nerve 40: 98–102, 2009

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