Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes
Article first published online: 11 APR 2011
Copyright © 2010 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 43, Issue 5, pages 652–656, May 2011
How to Cite
Padua, L., Stålberg, E., Caliandro, P., Muscogiuri, G., Pazzaglia, C., Sorice, G. P., Granata, G., Salomone, E., Pontecorvi, A. and Giaccari, A. (2011), Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes. Muscle Nerve, 43: 652–656. doi: 10.1002/mus.21935
- Issue published online: 11 APR 2011
- Article first published online: 11 APR 2011
- Manuscript Accepted: 4 OCT 2010
- diabetic polyneuropathy;
- single-fiber conduction velocity
The purpose of this study was to determine whether single-fiber conduction velocity (SF-CV) of a small number of axons increases sensitivity for identification of motor nerve conduction alterations in patients with diabetes.
Twenty-one consecutive diabetic patients in good metabolic control were studied. For each patient, conventional (C-CV) and SF-CV results were correlated with the presence of neuropathic symptoms.
Nine of 21 patients reported symptoms suggestive of mild nerve impairment. Three patients had abnormal sural nerve CV, 1 of whom also had abnormal motor nerve conduction. Eighteen patients had normal findings on conventional tests, 3 of whom had slowing of SF-CV.
SF-CV is able to detect mild myelin damage with higher sensitivity than conventional tests. The use of SF-CV may be a helpful tool in the early identification of diabetic polyneuropathy, and it may be useful for tailoring an approach to diabetic polyneuropathy. Muscle Nerve, 2011