Changes in muscle T2 and tissue damage after downhill running in mdx Mice
Article first published online: 12 APR 2011
Copyright © 2010 Wiley Periodicals, Inc.
Muscle & Nerve
Volume 43, Issue 6, pages 878–886, June 2011
How to Cite
Mathur, S., Vohra, R. S., Germain, S. A., Forbes, S., Bryant, N. D., Vandenborne, K. and Walter, G. A. (2011), Changes in muscle T2 and tissue damage after downhill running in mdx Mice. Muscle Nerve, 43: 878–886. doi: 10.1002/mus.21986
- Issue published online: 23 MAY 2011
- Article first published online: 12 APR 2011
- Manuscript Accepted: 7 DEC 2010
- magnetic resonance imaging;
- mdx mice;
- muscle damage;
- muscle T2;
- muscular dystrophy
In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice.
Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise.
A higher percentage of pixels with elevated T2 in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre-exercise (P < 0.001) and at each time-point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T2.
Downhill running provides a stimulus for inducing acute changes in muscle T2 in mdx mice. MRI is a non-invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010.