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Changes in muscle T2 and tissue damage after downhill running in mdx Mice

  1. Sunita Mathur PhD1,
  2. Ravneet S. Vohra BSc (PT)1,
  3. Sean A. Germain MA2,
  4. Sean Forbes PhD1,
  5. Nathan D. Bryant PhD2,
  6. Krista Vandenborne PhD1,
  7. Glenn A. Walter PhD2,*

Article first published online: 12 APR 2011

DOI: 10.1002/mus.21986

Issue

Muscle & Nerve

Muscle & Nerve

Volume 43, Issue 6, pages 878–886, June 2011

Additional Information

How to Cite

Mathur, S., Vohra, R. S., Germain, S. A., Forbes, S., Bryant, N. D., Vandenborne, K. and Walter, G. A. (2011), Changes in muscle T2 and tissue damage after downhill running in mdx Mice. Muscle Nerve, 43: 878–886. doi: 10.1002/mus.21986

Author Information

  1. 1

    Department of Physical Therapy, University of Florida, Gainesville, Florida, USA

  2. 2

    Department of Physiology and Functional Genomics, University of Florida, Box 100274, Gainesville, Florida 32610-0274, USA

*Department of Physiology and Functional Genomics,University of Florida, Box 100274, Gainesville, Florida 32610-0274, USA

Publication History

  1. Issue published online: 23 MAY 2011
  2. Article first published online: 12 APR 2011
  3. Manuscript Accepted: 7 DEC 2010

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Keywords:

  • magnetic resonance imaging;
  • mdx mice;
  • muscle damage;
  • muscle T2;
  • muscular dystrophy

Abstract

Introduction:

In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice.

Methods:

Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise.

Results:

A higher percentage of pixels with elevated T2 in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre-exercise (P < 0.001) and at each time-point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T2.

Conclusions:

Downhill running provides a stimulus for inducing acute changes in muscle T2 in mdx mice. MRI is a non-invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010.

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