Main Article

Reliability of the modified hammersmith functional motor scale in young children with spinal muscular atrophy†

  1. Kristin J. Krosschell PT, MA1,*,
  2. Charles B. Scott PhD2,
  3. Jo Anne Maczulski OTR/L3,
  4. Aga J. Lewelt MD4,
  5. Sandra P. Reyna MD5,
  6. Kathryn J. Swoboda MD, FACMG5,6,
  7. for Project Cure SMA2

Article first published online: 22 JUN 2011

DOI: 10.1002/mus.22040

Issue

Muscle & Nerve

Muscle & Nerve

Volume 44, Issue 2, pages 246–251, August 2011

Additional Information

How to Cite

Krosschell, K. J., Scott, C. B., Maczulski, J. A., Lewelt, A. J., Reyna, S. P., Swoboda, K. J. and for Project Cure SMA (2011), Reliability of the modified hammersmith functional motor scale in young children with spinal muscular atrophy. Muscle Nerve, 44: 246–251. doi: 10.1002/mus.22040

Author Information

  1. 1

    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Suite 1100, 645 North Michigan Avenue, Chicago, Illinois 60611, USA

  2. 2

    CBS Squared, Inc., Fort Washington, Pennsylvania, USA

  3. 3

    Pediatric Occupational Therapy Services, Chicago, Illinois, USA

  4. 4

    Division of Physical Medicine and Rehabilitation, University of Utah School of Medicine, Salt Lake City, Utah, USA

  5. 5

    Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA

  6. 6

    Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA

*Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Suite 1100, 645 North Michigan Avenue, Chicago, Illinois 60611, USA

  1. †

    Disclosure: The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development or the National Institutes of Health.

Publication History

  1. Issue published online: 13 JUL 2011
  2. Article first published online: 22 JUN 2011
  3. Accepted manuscript online: 1 FEB 2011 10:06AM EST
  4. Manuscript Accepted: 11 JAN 2011

Funded by

  • Public Health Services. Grant Number: UL1-RR025764
  • National Center for Research Resources. Grant Number: C06-RR11234

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Keywords:

  • MHFMS;
  • Modified Hammersmith Functional Motor Scale, outcome, spinal muscular atrophy, test–retest reliability

Abstract

Introduction: The test–retest reliability of the Modified Hammersmith Functional Motor Scale (MHFMS) in children with spinal muscular atrophy (SMA) ≤30 months of age was assessed. The age at which typically developing children (TD) achieve maximum MHFMS scores was also studied. Methods: Twenty-two children with SMA type II [mean age (SD) = 20 (5) months, range 9–30 months) were tested twice using the MHFMS. Twenty-five TD children [mean age (SD) = 18 (7) months, range 9–30 months) were tested once. Results: The average difference between MHFMS scores for SMA children was 0.18 [first assessment: mean (SD) = 12.8 (9.8); second assessment: mean (SD) = 13.0 (8.8)]. Reliability was excellent (ICC1,3 = 0.96, SEM 1.86). TD participants had MHFMS scores ranging from 36 to 40 [mean (SD) = 39.2 (1.2)] and achieved maximum test scores at 12 months of age. Discussion: MHFMS scores in young children with SMA type II showed excellent test–retest stability. This suggests that the MHFMS can be used reliably in this younger population for clinical trials and follow-up. Muscle Nerve, 2011

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