Research Article

Prevalence and risk factors of muscle complications secondary to statins

  1. Khalid El-Salem MD1,*,
  2. Bashar Ababneh MBBS2,
  3. Stacy Rudnicki MD3,
  4. Ahmad Malkawi MD4,
  5. Ali Alrefai MD1,
  6. Yousef Khader PhD5,
  7. Ruba Saadeh MD1,
  8. Mohammad Saydam MD1

Article first published online: 18 NOV 2011

DOI: 10.1002/mus.22205

Issue

Muscle & Nerve

Muscle & Nerve

Volume 44, Issue 6, pages 877–881, December 2011

Additional Information

How to Cite

El-Salem, K., Ababneh, B., Rudnicki, S., Malkawi, A., Alrefai, A., Khader, Y., Saadeh, R. and Saydam, M. (2011), Prevalence and risk factors of muscle complications secondary to statins. Muscle Nerve, 44: 877–881. doi: 10.1002/mus.22205

Author Information

  1. 1

    Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

  2. 2

    Department of Internal Medicine, Kansas City Medical Center, Kansas City, Kansas, USA

  3. 3

    Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

  4. 4

    Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

  5. 5

    Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan

*Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan

Publication History

  1. Issue published online: 18 NOV 2011
  2. Article first published online: 18 NOV 2011
  3. Accepted manuscript online: 14 JUN 2011 08:24AM EST
  4. Manuscript Accepted: 9 JUN 2011

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Keywords:

  • adverse reactions;
  • muscle;
  • prevalence;
  • risk factors;
  • statins

Abstract

Introduction: The aim of the study was to investigate the prevalence and risk factors of muscle complications among patients using statins. Methods: We conducted a prospective comparative study on 345 patients receiving statins and compared the findings with an age- and gender-matched control group of 85 subjects. Univariate and multivariate analyses with logistic regression models were used to study the association of different patient and disease characteristics with muscle complications. Results: Adverse reactions were reported by 21% of patients and 5.9% of controls (P = 0.0013). Objective weakness was found in 15% of the patients who reported muscle symptoms (3.2% of the total cohort), but not in controls. Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing these symptoms. Conclusions: Adverse reactions to statins may be more common than previously reported, and they may be affected by specific patient and disease characteristics. Muscle Nerve 2011

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