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Statin-associated changes in skeletal muscle function and stress response after novel or accustomed exercise

Authors

  • Benjamin M. Meador PhD,

    1. Department of Kinesiology, University of Illinois at Urbana–Champaign, Urbana, Illinois, USA
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  • Kimberly A. Huey PhD

    Corresponding author
    1. College of Pharmacy and Health Sciences, Drake University, 2507 University Avenue, Des Moines, Iowa 50311, USA
    • College of Pharmacy and Health Sciences, Drake University, 2507 University Avenue, Des Moines, Iowa 50311, USA
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Errata

This article is corrected by:

  1. Errata: Erratum: Statin-associated changes in skeletal muscle function and stress response after novel or accustomed exercise Volume 45, Issue 1, 149–150, Article first published online: 21 December 2011

Abstract

Introduction: The most common side effect of statins, myopathy, is more likely in exercisers. We investigated the interaction of statin treatment with novel vs. accustomed exercise on muscle function, heat shock protein (Hsp) expression, and caspase activation. Methods: Mice received daily cerivastatin or saline for 2 weeks, with/without wheel running (RW) (novel/sedentary). Accustomed groups completed 2 weeks of RW before statins. At 4 weeks, plantarflexor isometric force, Hsp25, αB-crystallin, caspase-3 and -9, and plasma creatine kinase (CK) were quantified. Results: Statins reduced force in sedentary and novel groups, compared with saline, by 15% and 27%, respectively. Muscle fatigability increased 21% and 30% with statins compared with saline in sedentary and novel groups, respectively. Accustomed exercise prevented statin-associated force loss and increased fatigability. CK did not correlate with functional outcomes. RW increased Hsp protein in all groups. Conclusion: Our results suggest that exercise prior to statin treatment can protect against decrements in muscle function. Muscle Nerve 2011

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