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Keywords:

  • flecainide;
  • peripheral neuropathy;
  • skin biopsy;
  • toxic neuropathy;
  • potassium channel

Abstract

Flecainide acetate is a classic Ic antiarrhythmic agent used to treat a variety of cardiac arrhythmias. Non-cardiac side effects usually affect the central nervous system. Few case reports of possible flecainide-induced peripheral neuropathy have been reported. We report this unique case in that flecainide-induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy. Muscle Nerve 45: 144–146, 2011